Immunoglobulin therapy ameliorates the phenotype and increases lifespan in the severely affected dystrophin–utrophin double knockout mice

Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder, caused by mutations in the dystrophin gene, affecting 1:3500–5000 boys worldwide. The lack of dystrophin induces degeneration of muscle cells and elicits an immune response characterized by an intensive secretion of pro-inflammator...

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Detaylı Bibliyografya
Yayımlandı:Eur J Hum Genet
Asıl Yazarlar: Nunes, Bruno Ghirotto, Loures, Flávio Vieira, Bueno, Heloisa Maria Siqueira, Cangussu, Erica Baroni, Goulart, Ernesto, Coatti, Giuliana Castello, Caldini, Elia Garcia, Condino-Neto, Antonio, Zatz, Mayana
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer International Publishing 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865115/
https://ncbi.nlm.nih.gov/pubmed/29255177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41431-017-0017-y
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