Low dystrophin levels increase survival and improve muscle pathology and function in dystrophin/utrophin double-knockout mice

Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disorder caused by the lack of functional dystrophin. There is no cure, but several clinical trials aimed to restore the synthesis of functional dystrophin are underway. The dystrophin levels needed for improvement of muscle pathology, fun...

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Detalhes bibliográficos
Main Authors: van Putten, Maaike, Hulsker, Margriet, Young, Courtney, Nadarajah, Vishna D., Heemskerk, Hans, van der Weerd, Louise, 't Hoen, Peter A. C., van Ommen, Gert-Jan B., Aartsma-Rus, Annemieke M.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2013
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659351/
https://ncbi.nlm.nih.gov/pubmed/23460734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-224170
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