Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice

Isocitrate dehydrogenase (IDH) 2 participates in the TCA cycle and catalyzes the conversion of isocitrate to α-ketoglutarate and NADP(+) to NADPH. In the mitochondria, IDH2 also plays a key role in protecting mitochondrial components from oxidative stress by supplying NADPH to both glutathione reduc...

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Publicado en:Sci Rep
Main Authors: White, Karessa, Kim, Mi-Jung, Han, Chul, Park, Hyo-Jin, Ding, Dalian, Boyd, Kevin, Walker, Logan, Linser, Paul, Meneses, Zaimary, Slade, Cole, Hirst, Jonathan, Santostefano, Katherine, Terada, Naohiro, Miyakawa, Takuya, Tanokura, Masaru, Salvi, Richard, Someya, Shinichi
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5864918/
https://ncbi.nlm.nih.gov/pubmed/29567975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23436-w
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