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The interplay between mutant p53 and the mevalonate pathway
Missense mutations in the TP53 gene lead to accumulation of dysfunctional TP53 proteins in tumors, showing oncogenic gain-of-function (GOF) activities. Stabilization of mutant TP53 (mutp53) is required for the GOF; however, the mechanisms by which mutp53 promotes cancer progression and how mutp53 st...
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| Udgivet i: | Cell Death Differ |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5864191/ https://ncbi.nlm.nih.gov/pubmed/29238070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-017-0026-y |
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