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Testing therapeutics in cell-based assays: Factors that influence the apparent potency of drugs

Identifying effective antivirals for treating Ebola virus disease (EVD) and minimizing transmission of such disease is critical. A variety of cell-based assays have been developed for evaluating compounds for activity against Ebola virus. However, very few reports discuss the variable assay conditio...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Postnikova, Elena, Cong, Yu, DeWald, Lisa Evans, Dyall, Julie, Yu, Shuiqing, Hart, Brit J., Zhou, Huanying, Gross, Robin, Logue, James, Cai, Yingyun, Deiuliis, Nicole, Michelotti, Julia, Honko, Anna N., Bennett, Richard S., Holbrook, Michael R., Olinger, Gene G., Hensley, Lisa E., Jahrling, Peter B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5864066/
https://ncbi.nlm.nih.gov/pubmed/29566079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0194880
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