Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint

Monopolar spindle 1 (Mps1) is a conserved apical kinase in the spindle assembly checkpoint (SAC) that ensures accurate segregation of chromosomes during mitosis. Mps1 undergoes extensive auto- and transphosphorylation, but the regulatory and functional consequences of these modifications remain uncl...

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Gepubliceerd in:Curr Biol
Hoofdauteurs: Combes, Guillaume, Barysz, Helena, Garand, Chantal, Gama Braga, Luciano, Alharbi, Ibrahim, Thebault, Philippe, Murakami, Luc, Bryne, Dominic P., Stankovic, Stasa, Eyers, Patrick A., Bolanos-Garcia, Victor M., Earnshaw, William C., Maciejowski, John, Jallepalli, Prasad V., Elowe, Sabine
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5863767/
https://ncbi.nlm.nih.gov/pubmed/29502948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2018.02.002
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