MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma

BACKGROUND & AIMS: Cholangiocarcinomas (CCA) are resistant to chemotherapy, so new therapeutic agents are needed. We performed a screen to identify small-molecule compounds that are active against CCAs. Levels of microRNA 21 (MIR21 or miRNA21) are increased in CCAs. We investigated whether miRNA...

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Vydáno v:Gastroenterology
Hlavní autoři: Lampis, Andrea, Carotenuto, Pietro, Vlachogiannis, Georgios, Cascione, Luciano, Hedayat, Somaieh, Burke, Rosemary, Clarke, Paul, Bosma, Else, Simbolo, Michele, Scarpa, Aldo, Yu, Sijia, Cole, Rebecca, Smyth, Elizabeth, Mateos, Javier Fernández, Begum, Ruwaida, Hezelova, Blanka, Eltahir, Zakaria, Wotherspoon, Andrew, Fotiadis, Nicos, Bali, Maria Antonietta, Nepal, Chirag, Khan, Khurum, Stubbs, Mark, Hahne, Jens C., Gasparini, Pierluigi, Guzzardo, Vincenza, Croce, Carlo M., Eccles, Suzanne, Fassan, Matteo, Cunningham, David, Andersen, Jesper B., Workman, Paul, Valeri, Nicola, Braconi, Chiara
Médium: Artigo
Jazyk:Inglês
Vydáno: W.B. Saunders 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5863695/
https://ncbi.nlm.nih.gov/pubmed/29113809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2017.10.043
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