Distinct Mechanisms of Pathogenic DJ-1 Mutations in Mitochondrial Quality Control

The deglycase and chaperone protein DJ-1 is pivotal for cellular oxidative stress responses and mitochondrial quality control. Mutations in PARK7, encoding DJ-1, are associated with early-onset familial Parkinson’s disease and lead to pathological oxidative stress and/or disrupted protein degradatio...

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Foilsithe in:Front Mol Neurosci
Main Authors: Strobbe, Daniela, Robinson, Alexis A., Harvey, Kirsten, Rossi, Lara, Ferraina, Caterina, de Biase, Valerio, Rodolfo, Carlo, Harvey, Robert J., Campanella, Michelangelo
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2018
Ábhair:
Neuroscience
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862874/
https://ncbi.nlm.nih.gov/pubmed/29599708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00068
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