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Distinct Mechanisms of Pathogenic DJ-1 Mutations in Mitochondrial Quality Control
The deglycase and chaperone protein DJ-1 is pivotal for cellular oxidative stress responses and mitochondrial quality control. Mutations in PARK7, encoding DJ-1, are associated with early-onset familial Parkinson’s disease and lead to pathological oxidative stress and/or disrupted protein degradatio...
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| Publicado no: | Front Mol Neurosci |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5862874/ https://ncbi.nlm.nih.gov/pubmed/29599708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00068 |
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