A role for TSPO in mitochondrial Ca(2+) homeostasis and redox stress signaling

The 18 kDa translocator protein TSPO localizes on the outer mitochondrial membrane (OMM). Systematically overexpressed at sites of neuroinflammation it is adopted as a biomarker of brain conditions. TSPO inhibits the autophagic removal of mitochondria by limiting PARK2-mediated mitochondrial ubiquit...

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Bibliografski detalji
Izdano u:Cell Death Dis
Glavni autori: Gatliff, Jemma, East, Daniel A, Singh, Aarti, Alvarez, Maria Soledad, Frison, Michele, Matic, Ivana, Ferraina, Caterina, Sampson, Natalie, Turkheimer, Federico, Campanella, Michelangelo
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Original Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520880/
https://ncbi.nlm.nih.gov/pubmed/28640253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.186
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