Does childhood trauma moderate polygenic risk for depression? A meta-analysis of 5,765 subjects from the Psychiatric Genomics Consortium

BACKGROUND: The heterogeneity of genetic effects on Major Depressive Disorder (MDD) may be partly attributable to moderation of genetic effects by environment, such as exposure to childhood trauma (CT). Indeed, previous findings in two independent cohorts showed evidence for interaction between poly...

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Publicado en:Biol Psychiatry
Main Authors: Peyrot, Wouter J, Van der Auwera, Sandra, Milaneschi, Yuri, Dolan, Conor V, Madden, Pamela AF, Sullivan, Patrick F, Strohmaier, Jana, Ripke, Stephan, Rietschel, Marcella, Nivard, Michel G, Mullins, Niamh, Montgomery, Grant W, Henders, Anjali K, Heat, Andrew C, Fisher, Helen L, Dunn, Erin C, Byrne, Enda M, Air, Tracy A, Baune, Bernhard T, Breen, Gerome, Levinson, Douglas F, Lewis, Cathryn M, Martin, Nick G, Nelson, Elliot N, Boomsma, Dorret I, Grabe, Hans J, Wray, Naomi R, Penninx, Brenda WJH
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862738/
https://ncbi.nlm.nih.gov/pubmed/29129318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2017.09.009
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