Does childhood trauma moderate polygenic risk for depression? A meta-analysis of 5,765 subjects from the Psychiatric Genomics Consortium

BACKGROUND: The heterogeneity of genetic effects on Major Depressive Disorder (MDD) may be partly attributable to moderation of genetic effects by environment, such as exposure to childhood trauma (CT). Indeed, previous findings in two independent cohorts showed evidence for interaction between poly...

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Bibliografski detalji
Izdano u:Biol Psychiatry
Glavni autori: Peyrot, Wouter J, Van der Auwera, Sandra, Milaneschi, Yuri, Dolan, Conor V, Madden, Pamela AF, Sullivan, Patrick F, Strohmaier, Jana, Ripke, Stephan, Rietschel, Marcella, Nivard, Michel G, Mullins, Niamh, Montgomery, Grant W, Henders, Anjali K, Heat, Andrew C, Fisher, Helen L, Dunn, Erin C, Byrne, Enda M, Air, Tracy A, Baune, Bernhard T, Breen, Gerome, Levinson, Douglas F, Lewis, Cathryn M, Martin, Nick G, Nelson, Elliot N, Boomsma, Dorret I, Grabe, Hans J, Wray, Naomi R, Penninx, Brenda WJH
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862738/
https://ncbi.nlm.nih.gov/pubmed/29129318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2017.09.009
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