Integrated analysis of genetic variation and gene expression reveals novel variant for increased warfarin dose requirement in African Americans

BACKGROUND: Warfarin is commonly used to control and prevent thromboembolic disorders. However, because of warfarin’s complex dose–requirement relationship, safe and effective use is challenging. Pharmacogenomics-guided warfarin dosing algorithms that include the well-established VKORC1 and CYP2C9 p...

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Pubblicato in:J Thromb Haemost
Autori principali: HERNANDEZ, W., GAMAZON, E. R., AQUINO-MICHAELS, K., SMITHBERGER, E., O’BRIEN, T. J., HARRALSON, A. F., TUCK, M., BARBOUR, A., CAVALLARI, L. H., PERERA, M. A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862636/
https://ncbi.nlm.nih.gov/pubmed/28135054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.13639
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