Ethnicity-Specific Pharmacogenetics: The Case of Warfarin In African Americans

Using a derivation cohort (N=349), we developed the first warfarin dosing algorithm that includes recently discovered polymorphisms in VKORC1 and CYP2C9 associated with warfarin dose requirement in African Americans (AAs). We tested our novel algorithm in an independent cohort of 129 AAs and compare...

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Detalhes bibliográficos
Main Authors: Hernandez, Wenndy, Gamazon, Eric R., Aquino-Michaels, Keston, Patel, Shitalben, O’Brien, Travis J., Harralson, Art F., Kittles, Rick A., Barbour, April, Tuck, Matthew, McIntosh, Samantha D., Douglas, Jacqueline N., Nicolae, Dan, Cavallari, Larisa H., Perera, Minoli A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4016191/
https://ncbi.nlm.nih.gov/pubmed/24018621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2013.34
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