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Accumulation of mechanical forces in tumors is related to hyaluronan content and tissue stiffness

Hyaluronan is abundant in the extracellular matrix of many desmoplastic tumors and determines in large part the tumor biochemical and mechanical microenvironment. Additionally, it has been identified as one of the major physiological barriers to the effective delivery of drugs to solid tumors and it...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Voutouri, Chrysovalantis, Stylianopoulos, Triantafyllos
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862434/
https://ncbi.nlm.nih.gov/pubmed/29561855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193801
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