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Indel detection from RNA-seq data: tool evaluation and strategies for accurate detection of actionable mutations

Driver somatic mutations are a hallmark of a tumor that can be used for diagnosis and targeted therapy. Mutations are primarily detected from tumor DNA. As dynamic molecules of gene activities, transcriptome profiling by RNA sequence (RNA-seq) is becoming increasingly popular, which not only measure...

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Detalhes bibliográficos
Publicado no:Brief Bioinform
Main Authors: Sun, Zhifu, Bhagwate, Aditya, Prodduturi, Naresh, Yang, Ping, Kocher, Jean-Pierre A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862335/
https://ncbi.nlm.nih.gov/pubmed/27473065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bib/bbw069
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