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1-Benzyl-indole-3-carbinol is a highly potent new small molecule inhibitor of Wnt/β-catenin signaling in melanoma cells that coordinately inhibits cell proliferation and disrupts expression of microphthalmia-associated transcription factor isoform-M

1-Benzyl-indole-3-carbinol (1-benzyl-I3C), a synthetic analogue of the crucifer-derived natural phytochemical I3C, displayed significantly wider sensitivity and anti-proliferative potency in melanoma cells than the natural compound. Unlike I3C, which targets mainly oncogenic BRAF-expressing cells, 1...

詳細記述

保存先:
書誌詳細
出版年:Carcinogenesis
主要な著者: Kundu, Aishwarya, Khouri, Michelle G, Aryana, Sheila, Firestone, Gary L
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862306/
https://ncbi.nlm.nih.gov/pubmed/29028954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgx103
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