Muc1 knockout potentiates murine lung carcinogenesis involving an epiregulin-mediated EGFR activation feedback loop

Mucin 1 (MUC1) is a tumor antigen that is aberrantly overexpressed in various cancers, including lung cancer. Our previous in vitro studies showed that MUC1 facilitates carcinogen-induced EGFR activation and transformation in human lung bronchial epithelial cells (HBECs), which along with other repo...

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Bibliographische Detailangaben
Veröffentlicht in:Carcinogenesis
Hauptverfasser: Xu, Xiuling, Chen, Wenshu, Leng, Shuguang, Padilla, Mabel T, Saxton, Bryanna, Hutt, Julie, Tessema, Mathewos, Kato, Kosuke, Kim, Kwang Chul, Belinsky, Steven A, Lin, Yong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
Schlagworte:
Biology, Genetics and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862300/
https://ncbi.nlm.nih.gov/pubmed/28472347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgx039
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