A Long-lived Mouse Lacking Both Growth Hormone and Growth Hormone Receptor: A New Animal Model for Aging Studies

Disruption of the growth hormone (GH) signaling pathway promotes insulin sensitivity and is associated with both delayed aging and extended longevity. Two kinds of long-lived mice—Ames dwarfs (df/df) and GH receptor gene–disrupted knockouts (GHRKO) are characterized by a suppressed GH axis with a si...

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Detalhes bibliográficos
Publicado no:J Gerontol A Biol Sci Med Sci
Main Authors: Gesing, Adam, Wiesenborn, Denise, Do, Andrew, Menon, Vinal, Schneider, Augusto, Victoria, Berta, Stout, Michael B., Kopchick, John J., Bartke, Andrzej, Masternak, Michal M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5861925/
https://ncbi.nlm.nih.gov/pubmed/27688483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glw193
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