A Long-lived Mouse Lacking Both Growth Hormone and Growth Hormone Receptor: A New Animal Model for Aging Studies

Disruption of the growth hormone (GH) signaling pathway promotes insulin sensitivity and is associated with both delayed aging and extended longevity. Two kinds of long-lived mice—Ames dwarfs (df/df) and GH receptor gene–disrupted knockouts (GHRKO) are characterized by a suppressed GH axis with a si...

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Vydáno v:J Gerontol A Biol Sci Med Sci
Hlavní autoři: Gesing, Adam, Wiesenborn, Denise, Do, Andrew, Menon, Vinal, Schneider, Augusto, Victoria, Berta, Stout, Michael B., Kopchick, John J., Bartke, Andrzej, Masternak, Michal M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5861925/
https://ncbi.nlm.nih.gov/pubmed/27688483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glw193
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