Digital PCR Quantitation of Muscle Mitochondrial DNA: Age, Fiber Type, and Mutation-Induced Changes

Definitive quantitation of mitochondrial DNA (mtDNA) and mtDNA deletion mutation abundances would help clarify the role of mtDNA instability in aging. To more accurately quantify mtDNA, we applied the emerging technique of digital polymerase chain reaction to individual muscle fibers and muscle homo...

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Bibliografiset tiedot
Julkaisussa:J Gerontol A Biol Sci Med Sci
Päätekijät: Herbst, Allen, Widjaja, Kevin, Nguy, Beatrice, Lushaj, Entela B, Moore, Timothy M, Hevener, Andrea L, McKenzie, Debbie, Aiken, Judd M, Wanagat, Jonathan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2017
Aiheet:
The Journal of Gerontology: BIOLOGICAL SCIENCES
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5861869/
https://ncbi.nlm.nih.gov/pubmed/28460005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glx058
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