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Human binge alcohol intake inhibits TLR4-MyD88 and TLR4-TRIF responses but not TLR3-TRIF pathway: HspA1A and PP1 play selective regulatory roles()

Binge/moderate alcohol suppresses TLR4-MyD88 pro-inflammatory cytokines. However, alcohol effects on TLR-TRIF signaling, especially after in vivo exposure in humans, are unclear. We performed comparative analysis of TLR4-MyD88, TLR4-TRIF and TLR3-TRIF pathways in human monocytes following binge alco...

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Vydáno v:J Immunol
Hlavní autoři: Muralidharan, Sujatha, Lim, Arlene, Catalano, Donna, Mandrekar, Pranoti
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5860983/
https://ncbi.nlm.nih.gov/pubmed/29445009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600924
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