The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action

Somatic mutations in spliceosome proteins lead to dysregulated RNA splicing and are observed in a variety of cancers. These genetic aberrations may offer a potential intervention point for targeted therapeutics. SF3B1, part of the U2 small nuclear RNP (snRNP), is targeted by splicing modulators, inc...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Finci, Lorenzo I., Zhang, Xiaofeng, Huang, Xiuliang, Zhou, Qiang, Tsai, Jennifer, Teng, Teng, Agrawal, Anant, Chan, Betty, Irwin, Sean, Karr, Craig, Cook, Andrew, Zhu, Ping, Reynolds, Dominic, Smith, Peter G., Fekkes, Peter, Buonamici, Silvia, Larsen, Nicholas A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5859971/
https://ncbi.nlm.nih.gov/pubmed/29491137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.311043.117
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