The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action

Somatic mutations in spliceosome proteins lead to dysregulated RNA splicing and are observed in a variety of cancers. These genetic aberrations may offer a potential intervention point for targeted therapeutics. SF3B1, part of the U2 small nuclear RNP (snRNP), is targeted by splicing modulators, inc...

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書目詳細資料
發表在:Genes Dev
Main Authors: Finci, Lorenzo I., Zhang, Xiaofeng, Huang, Xiuliang, Zhou, Qiang, Tsai, Jennifer, Teng, Teng, Agrawal, Anant, Chan, Betty, Irwin, Sean, Karr, Craig, Cook, Andrew, Zhu, Ping, Reynolds, Dominic, Smith, Peter G., Fekkes, Peter, Buonamici, Silvia, Larsen, Nicholas A.
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2018
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5859971/
https://ncbi.nlm.nih.gov/pubmed/29491137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.311043.117
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