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Strategy for designing hyperstable, non-natural protein-ligand complexes with sub-Å accuracy
If we truly understand proteins, we should be able to design functional proteins purposefully from scratch. While the de novo design of proteins has seen many successes(1–11), no small molecule ligand- or organic cofactor-binding protein has been designed entirely from first principles to achieve i)...
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| Publicado en: | Nat Chem |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5859929/ https://ncbi.nlm.nih.gov/pubmed/29168496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.2846 |
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