Functional Genomics Approach Identifies Novel Signaling Regulators of TGFα Ectodomain Shedding

Ectodomain shedding of cell-surface precursor proteins by metalloproteases generates important cellular signaling molecules. Of importance for disease is the release of ligands that activate the epidermal growth factor receptor (EGFR), such as transforming growth factor-alpha (TGFA), which is mostly...

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Vydáno v:Mol Cancer Res
Hlavní autoři: Wilson, Jennifer L., Kefaloyianni, Eirini, Stopfer, Lauren, Harrison, Christina, Sabbisetti, Venkata, Fraenkel, Ernest, Lauffenburger, Douglas A., Herrlich, Andreas
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5859574/
https://ncbi.nlm.nih.gov/pubmed/29018056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-17-0140
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