Optimization of Cholinesterase-Based Catalytic Bioscavengers Against Organophosphorus Agents

Organophosphorus agents (OPs) are irreversible inhibitors of acetylcholinesterase (AChE). OP poisoning causes major cholinergic syndrome. Current medical counter-measures mitigate the acute effects but have limited action against OP-induced brain damage. Bioscavengers are appealing alternative thera...

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Vydáno v:Front Pharmacol
Hlavní autoři: Lushchekina, Sofya V., Schopfer, Lawrence M., Grigorenko, Bella L., Nemukhin, Alexander V., Varfolomeev, Sergei D., Lockridge, Oksana, Masson, Patrick
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5859046/
https://ncbi.nlm.nih.gov/pubmed/29593539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00211
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