Genetic Reduction in Left Ventricular Protein Kinase C alpha and Adverse Ventricular Remodeling in Human Subjects

BACKGROUND: Inhibition of Protein Kinase C alpha (PKCα) enhances contractility and cardioprotection in animal models, but effects in humans are unknown. Genotypes at rs9912468 strongly associate with PRKCA expression in the left ventricle, enabling genetic approaches to measure effects of reduced PK...

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Опубликовано в: :Circ Genom Precis Med
Главные авторы: Hu, Ray, Morley, Michael P, Brandimarto, Jeffrey, Tucker, Nathan R, Parsons, Victoria A., Zhao, Sihai D, Meder, Benjamin, Katus, Hugo A, Rühle, Frank, Stoll, Monika, Villard, Eric, Cambien, François, Lin, Honghuang, Smith, Nicholas L, Felix, Janine F, Vasan, Ramachandran S., van der Harst, Pim, Newton-Cheh, Christopher, Li, Jin, Kim, Cecilia E, Hakonarson, Hakon, Hannenhalli, Sridhar, Ashley, Euan A, Moravec, Christine S, Tang, WH Wilson, Maillet, Marjorie, Molkentin, Jeffery D., Ellinor, Patrick T, Margulies, Kenneth B, Cappola, Thomas P
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5858599/
https://ncbi.nlm.nih.gov/pubmed/29540468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGEN.117.001901
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