Genetic Reduction in Left Ventricular Protein Kinase C alpha and Adverse Ventricular Remodeling in Human Subjects

BACKGROUND: Inhibition of Protein Kinase C alpha (PKCα) enhances contractility and cardioprotection in animal models, but effects in humans are unknown. Genotypes at rs9912468 strongly associate with PRKCA expression in the left ventricle, enabling genetic approaches to measure effects of reduced PK...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Circ Genom Precis Med
Main Authors: Hu, Ray, Morley, Michael P, Brandimarto, Jeffrey, Tucker, Nathan R, Parsons, Victoria A., Zhao, Sihai D, Meder, Benjamin, Katus, Hugo A, Rühle, Frank, Stoll, Monika, Villard, Eric, Cambien, François, Lin, Honghuang, Smith, Nicholas L, Felix, Janine F, Vasan, Ramachandran S., van der Harst, Pim, Newton-Cheh, Christopher, Li, Jin, Kim, Cecilia E, Hakonarson, Hakon, Hannenhalli, Sridhar, Ashley, Euan A, Moravec, Christine S, Tang, WH Wilson, Maillet, Marjorie, Molkentin, Jeffery D., Ellinor, Patrick T, Margulies, Kenneth B, Cappola, Thomas P
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5858599/
https://ncbi.nlm.nih.gov/pubmed/29540468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGEN.117.001901
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados