DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages

Protein SUMOylation has been reported to play a role in innate immune response, but the enzymes, substrates, and consequences of the specific inflammatory signaling events are largely unknown. Reactive oxygen species (ROS) are abundantly produced during macrophage activation and required for Toll-li...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Lao, Yimin, Yang, Kai, Wang, Zhaojun, Sun, Xueqing, Zou, Qiang, Yu, Xiaoyan, Cheng, Jinke, Tong, Xuemei, Yeh, Edward T. H., Yang, Jie, Yi, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857993/
https://ncbi.nlm.nih.gov/pubmed/29352108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.816769
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