DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages

Protein SUMOylation has been reported to play a role in innate immune response, but the enzymes, substrates, and consequences of the specific inflammatory signaling events are largely unknown. Reactive oxygen species (ROS) are abundantly produced during macrophage activation and required for Toll-li...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Lao, Yimin, Yang, Kai, Wang, Zhaojun, Sun, Xueqing, Zou, Qiang, Yu, Xiaoyan, Cheng, Jinke, Tong, Xuemei, Yeh, Edward T. H., Yang, Jie, Yi, Jing
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2018
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857993/
https://ncbi.nlm.nih.gov/pubmed/29352108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.816769
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