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Structures of human calpain-3 protease core with and without bound inhibitor reveal mechanisms of calpain activation
Limb-girdle muscular dystrophy type 2a arises from mutations in the Ca(2+)-activated intracellular cysteine protease calpain-3. This calpain isoform is abundant in skeletal muscle and differs from the main isoforms, calpain-1 and -2, in being a homodimer and having two short insertion sequences. The...
Uloženo v:
| Vydáno v: | J Biol Chem |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Biochemistry and Molecular Biology
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5857979/ https://ncbi.nlm.nih.gov/pubmed/29382717 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001097 |
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