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Insertion sequence 1 from calpain-3 is functional in calpain-2 as an internal propeptide

Calpains are intracellular, calcium-activated cysteine proteases. Calpain-3 is abundant in skeletal muscle, where its mutation-induced loss of function causes limb-girdle muscular dystrophy type 2A. Unlike the small subunit–containing calpain-1 and -2, the calpain-3 isoform homodimerizes through pai...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: McCartney, Christian-Scott E., Ye, Qilu, Campbell, Robert L., Davies, Peter L.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2018
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6240860/
https://ncbi.nlm.nih.gov/pubmed/30254072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004803
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