Structural and Inhibition Analysis Reveals the Mechanism of Selectivity of a Series of Aggrecanase Inhibitors

Several inhibitors of a series of cis-1(S)2(R)-amino-2-indanol-based compounds were reported to be selective for the aggrecanases, ADAMTS-4 and -5 over other metalloproteases. To understand the nature of this selectivity for aggrecanases, the inhibitors, along with the broad spectrum metalloprotease...

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Detalhes bibliográficos
Main Authors: Tortorella, Micky D., Tomasselli, Alfredo G., Mathis, Karl J., Schnute, Mark E., Woodard, Scott S., Munie, Grace, Williams, Jennifer M., Caspers, Nicole, Wittwer, Arthur J., Malfait, Anne-Marie, Shieh, Huey-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782012/
https://ncbi.nlm.nih.gov/pubmed/19586907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.029116
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