Structure of human ADAM-8 catalytic domain complexed with batimastat

The role of ADAM-8 in cancer and inflammatory diseases such as allergy, arthritis and asthma makes it an attractive target for drug development. Therefore, the catalytic domain of human ADAM-8 was expressed, purified and crystallized in complex with a hydroxamic acid inhibitor, batimastat. The cryst...

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Detalhes bibliográficos
Main Authors: Hall, Troii, Shieh, Huey-Sheng, Day, Jacqueline E., Caspers, Nicole, Chrencik, Jill E., Williams, Jennifer M., Pegg, Lyle E., Pauley, Adele M., Moon, Andrea F., Krahn, Joseph M., Fischer, David H., Kiefer, James R., Tomasselli, Alfredo G., Zack, Marc D.
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2012
Assuntos:
Structural Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370895/
https://ncbi.nlm.nih.gov/pubmed/22684055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309112015618
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