Mutations in the β-amyloid precursor protein in familial Alzheimer’s disease increase Aβ oligomer production in cellular models

Soluble oligomers of amyloid-β (Aβ) peptides (AβOs) contribute to neurotoxicity in Alzheimer’s disease (AD). However, it currently remains unknown whether an increase in AβOs is the common phenotype in cellular and animal models. Furthermore, it has not yet been established whether experimental stud...

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Detalhes bibliográficos
Publicado no:Heliyon
Main Authors: Ohshima, Yoichi, Taguchi, Katsutoshi, Mizuta, Ikuko, Tanaka, Masaki, Tomiyama, Takami, Kametani, Fuyuki, Yabe-Nishimura, Chihiro, Mizuno, Toshiki, Tokuda, Takahiko
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857613/
https://ncbi.nlm.nih.gov/pubmed/29560429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2018.e00511
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