K(V)4.3 Expression Modulates Na(V)1.5 Sodium Current

In cardiomyocytes, the voltage-gated transient outward potassium current (I(to)) is responsible for the phase-1 repolarization of the action potential (AP). Gain-of-function mutations in KCND3, the gene encoding the I(to) carrying K(V)4.3 channel, have been associated with Brugada syndrome (BrS). Wh...

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Bibliografiske detaljer
Udgivet i:Front Physiol
Main Authors: Portero, Vincent, Wilders, Ronald, Casini, Simona, Charpentier, Flavien, Verkerk, Arie O., Remme, Carol Ann
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Physiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857579/
https://ncbi.nlm.nih.gov/pubmed/29593552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00178
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