Elevated phospholipase D isoform 1 in Alzheimer's disease patients' hippocampus: Relevance to synaptic dysfunction and memory deficits

INTRODUCTION: Phospholipase D (PLD), a lipolytic enzyme that breaks down membrane phospholipids, is also involved in signaling mechanisms downstream of seven transmembrane receptors. Abnormally elevated levels of PLD activity are well-established in Alzheimer's disease (AD), implicating the two...

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Vydáno v:Alzheimers Dement (N Y)
Hlavní autoři: Krishnan, Balaji, Kayed, Rakez, Taglialatela, Giulio
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857521/
https://ncbi.nlm.nih.gov/pubmed/29560412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trci.2018.01.002
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