Functional Integrity of Synapses in the Central Nervous System of Cognitively Intact Individuals with High Alzheimer’s Disease Neuropathology Is Associated with Absence of Synaptic Tau Oligomers

BACKGROUND: Certain individuals, here referred to as Non-Demented with Alzheimer Neuropathology (NDAN), do not show overt neurodegeneration (N(-)) and remain cognitively intact despite the presence of plaques (A+) and tangles (T+) that would normally be consistent with fully symptomatic Alzheimer’s...

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Veröffentlicht in:J Alzheimers Dis
Hauptverfasser: Singh, Ayush, Allen, Dyron, Fracassi, Anna, Tumurbaatar, Batbayar, Natarajan, Chandramouli, Scaduto, Pietro, Woltjer, Randy, Kayed, Rakez, Limon, Agenor, Krishnan, Balaji, Taglialatela, Giulio
Format: Artigo
Sprache:Inglês
Veröffentlicht: IOS Press 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7836055/
https://ncbi.nlm.nih.gov/pubmed/33185603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-200716
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