Absence of amyloid β oligomers at the postsynapse and regulated synaptic Zn(2+) in cognitively intact aged individuals with Alzheimer’s disease neuropathology

BACKGROUND: Early cognitive impairment in Alzheimer Disease (AD) is thought to result from the dysfunctional effect of amyloid beta (Aβ) oligomers targeting the synapses. Some individuals, however, escape cognitive decline despite the presence of the neuropathologic features of AD (Aβ plaques and ne...

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Bibliografske podrobnosti
Main Authors: Bjorklund, Nicole L, Reese, Lindsay C, Sadagoparamanujam, V-M, Ghirardi, Valeria, Woltjer, Randall L, Taglialatela, Giulio
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403985/
https://ncbi.nlm.nih.gov/pubmed/22640423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-23
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