CCR5 mediates HIV-1 Tat-induced neuroinflammation and influences morphine tolerance, dependence, and reward

The HIV-1 regulatory protein, trans-activator of transcription (Tat), interacts with opioids to potentiate neuroinflammation and neurodegeneration within the CNS. These effects may involve the C-C chemokine receptor type 5 (CCR5); however, the behavioral contribution of CCR5 on Tat/opioid interactio...

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Detalhes bibliográficos
Publicado no:Brain Behav Immun
Main Authors: Gonek, Maciej, McLane, Virginia D., Stevens, David L., Lippold, Kumiko, Akbarali, Hamid I., Knapp, Pamela E., Dewey, William L., Hauser, Kurt F., Paris, Jason J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857418/
https://ncbi.nlm.nih.gov/pubmed/29146238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2017.11.006
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