Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy

Though motor neurons (MNs) selectively degenerate in amyotrophic lateral sclerosis (ALS), other cell types are likely involved in this disease. We recently generated rNLS8 mice in which human TDP-43 (hTDP-43) pathology could be reversibly induced in neurons and expected microglia would contribute to...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Spiller, Krista J., Restrepo, Clark R., Khan, Tahiyana, Dominique, Myrna A., Fang, Terry C., Canter, Rebecca G., Roberts, Christopher, Miller, Kelly R., Ransohoff, Richard M., Trojanowski, John Q., Lee, Virginia M-Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857237/
https://ncbi.nlm.nih.gov/pubmed/29463850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-018-0083-7
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