Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses

BACKGROUND: Patients with long QT syndrome due to rare loss-of-function mutations in the human ether-á-go-go-related gene (hERG) have prolonged QT interval, risk of arrhythmias, increased secretion of insulin and incretins and impaired glucagon response to hypoglycemia. This is caused by a dysfuncti...

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Библиографические подробности
Опубликовано в: :BMC Genet
Главные авторы: Engelbrechtsen, Line, Mahendran, Yuvaraj, Jonsson, Anna, Gjesing, Anette Prior, Weeke, Peter E., Jørgensen, Marit E., Færch, Kristine, Witte, Daniel R., Holst, Jens J., Jørgensen, Torben, Grarup, Niels, Pedersen, Oluf, Vestergaard, Henrik, Torekov, Signe, Kanters, Jørgen K., Hansen, Torben
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2018
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857134/
https://ncbi.nlm.nih.gov/pubmed/29548277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12863-018-0602-2
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