Patients With Long-QT Syndrome Caused by Impaired hERG-Encoded K(v)11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated With Reactive Hypoglycemia

BACKGROUND: Loss-of-function mutations in hERG (encoding the K(v)11.1 voltage-gated potassium channel) cause long-QT syndrome type 2 (LQT2) because of prolonged cardiac repolarization. However, K(v)11.1 is also present in pancreatic α and β cells and intestinal L and K cells, secreting glucagon, ins...

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Опубликовано в: :Circulation
Главные авторы: Hyltén-Cavallius, Louise, Iepsen, Eva W., Wewer Albrechtsen, Nicolai J., Svendstrup, Mathilde, Lubberding, Anniek F., Hartmann, Bolette, Jespersen, Thomas, Linneberg, Allan, Christiansen, Michael, Vestergaard, Henrik, Pedersen, Oluf, Holst, Jens J., Kanters, Jørgen K., Hansen, Torben, Torekov, Signe S.
Формат: Artigo
Язык:Inglês
Опубликовано: Lippincott Williams & Wilkins 2017
Предметы:
Original Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5412733/
https://ncbi.nlm.nih.gov/pubmed/28235848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.116.024279
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