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Patients With Long-QT Syndrome Caused by Impaired hERG-Encoded K(v)11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated With Reactive Hypoglycemia
BACKGROUND: Loss-of-function mutations in hERG (encoding the K(v)11.1 voltage-gated potassium channel) cause long-QT syndrome type 2 (LQT2) because of prolonged cardiac repolarization. However, K(v)11.1 is also present in pancreatic α and β cells and intestinal L and K cells, secreting glucagon, ins...
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| Опубликовано в: : | Circulation |
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| Главные авторы: | , , , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Lippincott Williams & Wilkins
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5412733/ https://ncbi.nlm.nih.gov/pubmed/28235848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.116.024279 |
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