Patients With Long-QT Syndrome Caused by Impaired hERG-Encoded K(v)11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated With Reactive Hypoglycemia

BACKGROUND: Loss-of-function mutations in hERG (encoding the K(v)11.1 voltage-gated potassium channel) cause long-QT syndrome type 2 (LQT2) because of prolonged cardiac repolarization. However, K(v)11.1 is also present in pancreatic α and β cells and intestinal L and K cells, secreting glucagon, ins...

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發表在:Circulation
Main Authors: Hyltén-Cavallius, Louise, Iepsen, Eva W., Wewer Albrechtsen, Nicolai J., Svendstrup, Mathilde, Lubberding, Anniek F., Hartmann, Bolette, Jespersen, Thomas, Linneberg, Allan, Christiansen, Michael, Vestergaard, Henrik, Pedersen, Oluf, Holst, Jens J., Kanters, Jørgen K., Hansen, Torben, Torekov, Signe S.
格式: Artigo
語言:Inglês
出版: Lippincott Williams & Wilkins 2017
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Original Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5412733/
https://ncbi.nlm.nih.gov/pubmed/28235848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.116.024279
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