A Population Pharmacokinetic Model to Predict the Individual Starting Dose of Tacrolimus Following Pediatric Renal Transplantation

BACKGROUND: Multiple clinical, demographic, and genetic factors affect the pharmacokinetics of tacrolimus in children, yet in daily practice, a uniform body-weight based starting dose is used. It can take weeks to reach the target tacrolimus pre-dose concentration. OBJECTIVES: The objectives of this...

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Vydáno v:Clin Pharmacokinet
Hlavní autoři: Andrews, Louise M., Hesselink, Dennis A., van Gelder, Teun, Koch, Birgit C. P., Cornelissen, Elisabeth A. M., Brüggemann, Roger J. M., van Schaik, Ron H. N., de Wildt, Saskia N., Cransberg, Karlien, de Winter, Brenda C. M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2017
Témata:
Original Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856873/
https://ncbi.nlm.nih.gov/pubmed/28681225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-017-0567-8
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