Estrogen receptor α drives pro-resilient transcription in mouse models of depression

Most people exposed to stress do not develop depression. Animal models have shown that stress resilience is an active state that requires broad transcriptional adaptations, but how this homeostatic process is regulated remains poorly understood. In this study, we analyze upstream regulators of genes...

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Udgivet i:Nat Commun
Main Authors: Lorsch, Zachary S., Loh, Yong-Hwee Eddie, Purushothaman, Immanuel, Walker, Deena M., Parise, Eric M., Salery, Marine, Cahill, Michael E., Hodes, Georgia E., Pfau, Madeline L., Kronman, Hope, Hamilton, Peter J., Issler, Orna, Labonté, Benoit, Symonds, Ann E., Zucker, Matthew, Zhang, Tie Yuan, Meaney, Michael J., Russo, Scott J., Shen, Li, Bagot, Rosemary C., Nestler, Eric J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856766/
https://ncbi.nlm.nih.gov/pubmed/29549264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03567-4
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