Potent Inhibitors of Mycobacterium tuberculosis Growth Identified by Using in-Cell NMR-based Screening

In-cell NMR spectroscopy was used to screen for drugs that disrupt the interaction between prokaryotic ubiquitin like protein, Pup, and mycobacterial proteasome ATPase, Mpa. This interaction is critical for Mycobacterium tuberculosis resistance against nitric oxide (NO) stress; interruption of this...

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Veröffentlicht in:ACS Chem Biol
Hauptverfasser: DeMott, Christopher M., Girardin, Roxie, Cobbert, Jacqueline, Reverdatto, Sergey, Burz, David S., McDonough, Kathleen, Shekhtman, Alexander
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856640/
https://ncbi.nlm.nih.gov/pubmed/29359908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00879
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