PIK3CA C2 domain deletions hyperactivate phosphoinositide 3-kinase (PI3K), generate oncogene dependence and are exquisitely sensitive to PI3Kα inhibitors

PURPOSE: We describe herein a novel P447_L455 deletion in the C2 domain of PIK3CA in a patient with an ER+ breast cancer with an excellent response to the PI3Kα inhibitor alpelisib. Although PIK3CA deletions are relatively rare, a significant portion of deletions cluster within amino acids 446–460 o...

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Publicado no:Clin Cancer Res
Main Authors: Croessmann, Sarah, Sheehan, Jonathan H., Lee, Kyung-min, Sliwoski, Gregory, He, Jie, Nagy, Rebecca, Riddle, David, Mayer, Ingrid, Balko, Justin M., Lanman, Richard, Miller, Vincent A., Cantley, Lewis C., Meiler, Jens, Arteaga, Carlos L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856622/
https://ncbi.nlm.nih.gov/pubmed/29284706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-2141
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