Karyopherin α-3 is a key protein in the pathogenesis of spinocerebellar ataxia type 3 controlling the nuclear localization of ataxin-3

Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disorder caused by a CAG expansion in the ATXN3 gene leading to a polyglutamine expansion in the ataxin-3 protein. The nuclear presence and aggregation of expanded ataxin-3 are critical steps in disease pathogenesis. To identify novel thera...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sowa, Anna Sergeevna, Martin, Elodie, Martins, Inês Morgado, Schmidt, Jana, Depping, Reinhard, Weber, Jonasz Jeremiasz, Rother, Franziska, Hartmann, Enno, Bader, Michael, Riess, Olaf, Tricoire, Hervé, Schmidt, Thorsten
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856529/
https://ncbi.nlm.nih.gov/pubmed/29476013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716071115
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