Ataxin-3, The Spinocerebellar Ataxia Type 3 Neurodegenerative Disorder Protein, Affects Mast Cell Functions

Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph Disease, is a progressive neurodegenerative disorder characterized by loss of neuronal matter due to the expansion of the CAG repeat in the ATXN3/MJD1 gene and subsequent ataxin-3 protein. Although the underlying pathogenic protein e...

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Bibliographic Details
Main Authors: Anna S. Sowa, Eva Haas, Jeannette Hübener-Schmid, Axel Lorentz
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
ataxin-3
MJD
SCA3
mast cell
cytokine
neurodegeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.870966/full
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